Chondrosarcomas

What are Chondrosarcomas?

Chondrosarcoma is a type of bone cancer that develops in cartilage cells.  What is the Pathology of Chondrosarcomas? The pathology of chondrosarcomas is: -Etiology: The cause of chondrosarcomas is unknown.  -Genes involved: IDH, CDKN2A, and COL2A1. -Pathogenesis: The sequence of…
Chordomas

What are Osteochondromas?

Osteochondromas are an overgrowth of cartilage and bone that happens at the end of the bone near the growth plate. What is the Pathology of Osteochondromas? The pathology of osteochondromas is: -Etiology: The cause of osteochondromas is associated with loss…
Chordomas

What are Chordomas?

Chondroma is a benign cartilaginous tumor, which is encapsulated with a lobular growing pattern.  What is the Pathology of Chondromas? The pathology of chondromas is: -Etiology: The cause of chondromas is unknown.  -Genes involved: IDH1, IDH2. -Pathogenesis: The sequence of…
Cartilage Tumors

What are Cartilage Tumors?

Cartilage tumors, also known as chondrogenic tumors, are a type of bone tumor that develops in cartilage and are divided into non-cancerous, cancerous, and intermediate locally aggressive types. Examples of cartilage-forming tumors include:  ChordomasOsteochondromasChondrosarcomas
Osteosarcoma

What is an Osteosarcoma?

Osteosarcoma is a high-grade malignant primary central sarcoma of bone characterized by the presence of an osteoid extracellular matrix. What is the Pathology of Osteosarcoma? The pathology of osteosarcoma is: -Etiology: The cause of osteosarcoma is unknown. -Genes involved: TP53,…
Osteoblastoma

What is an Osteoblastoma?

Osteoblastoma is a rare benign bone-forming neoplasm which produces woven bone spicules, which are bordered by prominent osteoblasts. What is the Pathology of Osteoblastoma? The pathology of osteoblastoma is: -Etiology: The cause of osteoblastoma is unknown. -Genes involved: MDM2, TP53,…
Osteoid Osteoma

What is an Osteoid Osteoma?

Osteoid osteoma is a benign bone tumor that arises from osteoblasts and some components of osteoclasts.  What is the Pathology of Osteoid Osteoma? The pathology of osteoid osteoma is: -Etiology: The cause of osteoid osteoma remains uncertain.   -Genes involved: YWHAH…
Bone Tumors

What are Bone Tumors?

Bone tumors are an abnormal growth of tissue in bone, traditionally classified as benign or malignant. Examples of bone tumors include:  Osteoid osteomaOsteoblastomaOsteosarcoma
Skeletal Syphilis

What is Skeletal Syphilis?

Skeletal syphilis or osseous syphilis bony involvement by Treponema pallidum. What is the Pathology of Skeletal Syphilis? The pathology of skeletal syphilis is: -Etiology: The cause of skeletal syphilis is bacterium treponema pallidum  -Genes involved: None. -Pathogenesis: The sequence of…
Mycobacterial Osteomyelitis

What is Mycobacterial Osteomyelitis?

Mycobacterial osteomyelitis is the infection of the bone or the bone marrow by mycobacterium tuberculosis. What is the Pathology of Mycobacterial Osteomyelitis? The pathology of Mycobacterial osteomyelitis is: -Etiology: The cause of mycobacterial osteomyelitis is Mycobacterium tuberculosis -Genes involved: None.…